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KMID : 0387820030100020269
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Clinical Pediatric Hematology-Oncology
2003 Volume.10 No. 2 p.269 ~ p.276
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A Case of Idiopathic Hypereosinophilic Syndrome Treated Successfully with Hydroxyurea and Interferon alpha-2b
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Yang Gi-Hoon
Park Eun-Young
Jung Hye-Lim
Kim Deok-Soo
Shim Jae-Won
Shim Jung-Yeon
Park Moon-Soo
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Abstract
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The idiopathic hypereosinophilic syndromes are rare hematologic disorders showing a wide spectrum of diseases with eosinophilia and associated organ damage. Three criteria for diagnosis include persistent eosinophilia of at least 1,500 eosinophils/mm3 for longer than 6 months, or death before 6 months with signs and symptoms of hypereosinophilic disease; lack of evidence for parasitic, allergic or other known causes of eosinophilia; and signs and symptoms of organ involvement. We report a case of a 8 month-old male patient who had persistent marked eosinophilia reaching peak eosinophil count more than 100,000/mm3, and organ dysfunction involving the bone marrow, heart, brain, lung and spleen. This patient, who did not respond to administration of prednisolone or hydroxyurea alone, has been treated successfully with hydroxyurea and interferon alpha-2b combination therapy.
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KEYWORD
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Idiopathic Hypereosinophilic Syndrome, Hydroxyurea, Interferon alpha-2b
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